We Design The Best Solutions With Care
Services
Route Scouting
Process Development
Custom Synthesis
Scale Up
Asymmetric Synthesis
Route Scouting
Evaluation of potential routes to synthesize the target molecule(s). The proposed synthetic routes are discussed and will incorporate the collective experience of our scientific team. Process economics, scalability, safety and environmental considerations are key features of the proposal.
Process Development
The selected route is established in the laboratory on a scale as per the client requirements. Analytical methods are developed to characterize the intermediates and final product. Processes to be scaled-up undergo a systematic study of the relevant parameters influencing the yield and quality of the product. Initial safety parameters study will be undertaken at this stage.
Custom Synthesis
Fluorochem undertakes custom synthesis of key intermediates and active substances for innovator companies. We have the expertise in synthesizing diverse classes of molecules and offer gram to ton quantities in a cost-effective manner.
Scale Up
Larger quantities may be synthesized in the pilot plant facility at our partners. A summary of the parameters can be established for further transfer of the product to manufacturing facilities.
Capabilities include reactions from –78°C to +250°C; handling of hazardous reagents such as NaH, n-BuLi, Pd/C etc.
Asymmetric synthesis
- Fluorochem has an expertise in development and scale-up of asymmetric synthesis
- Synthesis of chiral building blocks.
- Synthesis of chiral drug intermediates.
- Design and development of chiral ligands.
The Reactions That We Undertake Include
- Grignard Reaction
- Nitration
- Oxidation reactions
- High temperature/high pressure oxidation
- Suzuki reaction
- Catalytic hydrogenation
- Sandmeyer reaction
- Chiral synthesis
- Chiral resolution and racemization.
- Hetero Diels Alder Reaction
- Friedel-Crafts Reaction
- Hazardous materials handling:
- Chlorine
- Bromine
- Chlorosulfonic acid
- Low temperature reaction: –80°C
- High temperature reaction: +260°C
- High pressure reaction: 10 kg/cm²
